a Section of Endocrinology John Buhler Research Centre, University of Manitoba , Winnipeg , Manitoba , Canada. b Department of Medicine, Division of Cardiology , St Michael's Hospital, University of Toronto , Toronto , Ontario , Canada. c St. Michael's Hospital , Keenan Research Centre for Biomedical Science , Toronto , Ontario , Canada. d Primary Care Initiatives, Canadian Heart Research Centre , Toronto , Ontario , Canada. e Division of Nephrology , St. Michael's Hospital , Toronto , Ontario , Canada.